SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury
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چکیده
منابع مشابه
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain
Oligomeric forms of alpha-synuclein are emerging as key mediators of pathogenesis in Parkinson's disease. Our understanding of the exact contribution of alpha-synuclein oligomers to disease is limited by the lack of a technique for their specific detection. We describe a novel method, the alpha-synuclein proximity ligation assay, which specifically recognizes alpha-synuclein oligomers. In a bli...
متن کاملCurrent Opportunities for Clinical Monitoring of Axonal Pathology in Traumatic Brain Injury
Traumatic brain injury (TBI) is a multidimensional and highly complex disease commonly resulting in widespread injury to axons, due to rapid inertial acceleration/deceleration forces transmitted to the brain during impact. Axonal injury leads to brain network dysfunction, significantly contributing to cognitive and functional impairments frequently observed in TBI survivors. Diffuse axonal inju...
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Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2015
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-015-1506-0